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Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases

Chong Liu, Dingfeng Su

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 35-40 doi: 10.1007/s11684-012-0171-0

Abstract: production through “the cholinergic anti-inflammatory pathway,” more specifically via the α7nicotinic acetylcholine receptor (α7nAChR).

Keywords： α7 nicotinic acetylcholine receptor     cardiovascular diseases     baroreflex sensitivity    

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Putative Mode of Action of the Monoterpenoids Linalool, Methyl Eugenol, Estragole, and Citronellal on Ligand-Gated Ion Channels Article

Amy S. Li, Akimasa Iijima, Junhao Huang, Qing X. Li, Yongli Chen

Engineering 2020, Volume 6, Issue 5,   Pages 541-545 doi: 10.1016/j.eng.2019.07.027

Abstract: It is well-known that the γ-aminobutyric acid type A receptors (GABAARs) and nicotinicacetylcholine receptor (nAChR) are primary molecular targets of the synthetic insecticides used in the

Keywords： Essential oil     γ-aminobutyric acid type A receptor     Linalool     Monoterpenoid     Nicotinic acetylcholinereceptor    

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Resistance of large deformation of the Wushaoling Tunnel F7 soft fault

ZHAO Xufeng, CHEN Haiming, WANG Chunmiao

Frontiers of Structural and Civil Engineering 2007, Volume 1, Issue 1,   Pages 123-127 doi: 10.1007/s11709-007-0013-3

Abstract: In this article, the mechanical characteristics of the squeeze of the F7 fault of the Wushaoling Tunnel

Keywords： F7     deformation     appropriate     construction     mechanical    

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China Engineering Science 2005 Volume 7 Contents

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Strategic Study of CAE 2005, Volume 7, Issue 12,   Pages 98-102

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Acid Orange 7 degradation using methane as the sole carbon source and electron donor

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 3, doi: 10.1007/s11783-021-1468-5

Abstract:

• AO7 degradation was coupled with anaerobic methane oxidation.

Keywords： Azo dyes     AO7 degradation     Anaerobic methane oxidation     Microbial community     ANME-2d    

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Time-dependent metabolomics uncover dynamic metabolic adaptions in MCF-7 cells exposed to bisphenol A

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 1, doi: 10.1007/s11783-023-1604-5

Abstract:

● Metabolomic temporal profiling of cells exposed to xenobiotics.

Keywords： Metabolomics     BPA     MCF-7     Temporal profiling     Metabolic adaption     Dysregulation correlation    

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Research progress on human infection with avian influenza H7N9

Xiaoxin Wu, Lanlan Xiao, Lanjuan Li

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 8-20 doi: 10.1007/s11684-020-0739-z

Abstract: Since the first case of novel H7N9 infection was reported, China has experienced five epidemics of H7N9During the fifth wave, a highly pathogenic H7N9 strain emerged.epithelial sialic acid 2-6 receptor has increased.characteristics of H7N9, the key gene mutations of the virus, and H7N9 vaccine, thus providing a scientificbasis for further monitoring and prevention of H7N9 influenza epidemics.

Keywords： H7N9     pandemic     epidemiology     mutations     vaccine     influenza    

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A study on rapid acid chrome black (MB 7) spectrophotometric determination of ClO

Jing DONG, Huilong WANG

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 2,   Pages 245-251 doi: 10.1007/s11705-010-1003-x

Abstract: and convenient method for the determination of ClO in water was developed by using acid chrome black 7(MB 7) spectrophotometry in this paper.

Keywords： chlorine dioxide     2     6-dinitro-p-cresol (DNPC)     aluminum oxide     water treatment     MB 7 spectrophotometry    

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Erratum to “After Highflyer Crashes, Airborne Wind Energy Regroups” [Engineering 7 (2021) 277–279]

Peter Weiss

Engineering 2021, Volume 7, Issue 10,   Pages 1506-1506 doi: 10.1016/j.eng.2021.08.004

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Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies

Peter B. Alexander,Xiao-Fan Wang

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 134-138 doi: 10.1007/s11684-015-0396-9

Abstract: In this review, we discuss the main known mechanisms of resistance to receptor tyrosine kinase inhibitorsoutput, and consider the problems of signaling pathway redundancy and how the activation of different receptor

Keywords： targeted therapy     drug resistance     receptor tyrosine kinases     cancer    

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Universal influenza virus vaccines: what can we learn from the human immune response following exposure to H7

Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 471-479 doi: 10.1007/s11684-017-0602-z

Abstract: we review what is known about the human humoral immune response to vaccination and infection with H7H5 hemagglutinin, which induces antibody responses mostly restricted to the group 1 stalk domain, H7

Keywords： universal influenza virus vaccine     hemagglutinin stalk     H7N9    

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Compiling of comprehensive data of human infections with novel influenza A (H7N9) virus

Ying Wu, George F. Gao

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 275-276 doi: 10.1007/s11684-013-0285-z

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RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 143-155 doi: 10.1007/s11684-022-0929-y

Abstract: Moreover, previous studies confirmed that let-7c-5p, a well-known microRNA, can act as a tumour suppressorHowever, whether RGS16 can promote the progression of glioma and whether it is regulated by miR let-7cMoreover, RGS16 was validated as a direct target gene of miR let-7c-5p.The overexpression of miR let-7c-5p obviously downregulated the expression of RGS16, and knocking downmiR let-7c-5p had the opposite effect.

Keywords： RGS16     let-7c-5p     glioma     proliferation     migration    

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Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 808-814 doi: 10.1007/s11684-021-0878-x

Abstract: T, p.R2063W; c.7097G>A, p.G2366D; c.8569G>T, p.E2857*; c.3625_3635del, p.S1209fs) variants in COL7A1

Keywords： epidermolysis bullosa     LAMA3     COL7A1     KRT5     Chinese families    

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Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factorreceptor 2-negative (HR

Wenjie Zhu, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 208-220 doi: 10.1007/s11684-020-0795-4

Abstract: New targeted therapies have been developed to overcome resistance to endocrine therapy (ET) and improve the outcome of HR /HER2 advanced breast cancer (ABC). We conducted a meta-analysis and systemic review on randomized controlled trials evaluating various targeted therapies in combination with ET in HR /HER2 ABC. PUBMED and EMBASE databases were searched for eligible trials. Hazard ratios (HRs) for progression-free survival (PFS), odds ratios (ORs) for objective response rate (ORR), clinical benefit rate (CBR), and toxicity were meta-analyzed. Twenty-six studies with data on 10 347 patients were included and pooled. The addition of cyclin-dependent kinase 4/6 inhibitors to ET significantly improved median PFS (pooled HR= 0.547, <0.001), overall survival (pooled HR= 0.755, <0.001), and tumor response rates (ORR, pooled OR= 1.478, <0.001; CBR, pooled OR= 1.201, <0.001) with manageable toxicities (pooled OR= 3.280, <0.001). The mammalian targets of rapamycin inhibitors and exemestane were not clinically beneficial for this pooled population including ET-naïve and ET-resistant patients. Moderate improvement in PFS (pooled HR= 0.686, <0.001) yet pronounced toxicities (pooled OR= 2.154, <0.001) were noted in the combination of phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitors with fulvestrant. Future studies are warranted to optimize the population and the dosing sequence of these available options.

Keywords： endocrine-resistant     HR+/HER2- advanced breast cancer     randomized clinical trials     meta-analysis     targeted therapy    

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Title Author Date Type Operation

Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases

Chong Liu, Dingfeng Su

Journal Article

Putative Mode of Action of the Monoterpenoids Linalool, Methyl Eugenol, Estragole, and Citronellal on Ligand-Gated Ion Channels

Amy S. Li, Akimasa Iijima, Junhao Huang, Qing X. Li, Yongli Chen

Journal Article

Resistance of large deformation of the Wushaoling Tunnel F7 soft fault

ZHAO Xufeng, CHEN Haiming, WANG Chunmiao

Journal Article

China Engineering Science 2005 Volume 7 Contents

null

Journal Article

Acid Orange 7 degradation using methane as the sole carbon source and electron donor

Journal Article

Time-dependent metabolomics uncover dynamic metabolic adaptions in MCF-7 cells exposed to bisphenol A

Journal Article

Research progress on human infection with avian influenza H7N9

Xiaoxin Wu, Lanlan Xiao, Lanjuan Li

Journal Article

A study on rapid acid chrome black (MB 7) spectrophotometric determination of ClO

Jing DONG, Huilong WANG

Journal Article

Erratum to “After Highflyer Crashes, Airborne Wind Energy Regroups” [Engineering 7 (2021) 277–279]

Peter Weiss

Journal Article

Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies

Peter B. Alexander,Xiao-Fan Wang

Journal Article

Universal influenza virus vaccines: what can we learn from the human immune response following exposure to H7

Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer

Journal Article

Compiling of comprehensive data of human infections with novel influenza A (H7N9) virus

Ying Wu, George F. Gao

Journal Article

RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway

Journal Article

Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in

Journal Article

Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factorreceptor 2-negative (HR

Wenjie Zhu, Binghe Xu

Journal Article